Making Progress in Cancer Therapies-The Story of Clay Siegall

For the longest time, everyone has believed that the only way to combat cancer was through radiotherapy and chemotherapy. However, it is now emerging that it is possible to get better treatment outcomes by using advanced antibody-drug conjugates which deliver cancer-killing agents directly to the tumor cells. One of the antibody conjugates which have been developed by Seattle Genetics is ADCETRIS. The drug was approved for use by the FDA and has become popular in the treatment of relapsed Hodgkin lymphoma. The drug has so far been endorsed for use in more than 65countries.

Clay Siegall is the founder and CEO of Seattle Genetics, a Seattle based Clinical Trials Company. He has been working on getting better therapies to deal with cancer for the past two decades. He has a Bachelor of Science degree in Zoology from the University of Maryland and a Ph.D. in genetics from the University of Washington. He says that in addition to the FDA approved ADC; the clinical trials company is working towards the creation of other innovative therapies which will treat blood cancers and solid tumors.

The primary goal of their research is to improve the treatment outcomes in their patients. Clay says that at an early age, he watched a close person to him fight cancer, and the saddest part was that the medication seemed to have been tougher on his body than the tumors themselves. The past two decades have not been easy for Clay and his company. He confesses that there were times when they didn’t have funds to provide basics such as worker salaries. However, he has been very active in both private and public fundraising. He was in charge of the IPO which led to the company being listed on NASDAQ as SGEN.

Clay states that contrary to popular belief and practices, his company is not planning to sell off to big pharmaceuticals as it happens when the small biotech companies start making progress in their research. He confided that they were expanding their facilities because they were in Seattle to stay, and their goal was to provide efficient ADC technologies for many other cancer types.

Waiakea Water Makes Healthy Living Easy

Healthy living and conservationism have often been seen as moving hand in hand across the 21st-century which has been seen in recent years with the creation of the Waiakea Water brand in 2012. This impressive company believes in the development of a healthy water option alongside maintaining a socially responsible company outlook coupled with a belief in giving back to both the planet and local communities.

Waiakea Water has now been rewarded with its fast growth rate of more than 1,000 percent from 2014 to 2016 with a position in the top 500 fastest growing companies in the world published by the Inc. Magazine 5,000 Conference. Founder Ryan Emmons recently explained gaining a position on what is seen as an exclusive list of the top 500 entrants has long been an aim of his company which was given the position 414 for 2017 by the magazine.

The origins of Waiakea Water can be traced to the periods of time spent by the family of Ryan Emmons on the Big Island of Hawaii close to the Mauna Loa volcano where the volcanic filtration taking place in this bottled water product takes place. A high mineral and pH level was seen in the water the Emmons family were drinking led Ryan Emmons to take the water directly to the people of the world in the form of his socially responsible brand.

Achieving commercial success is not the overall aim of Ryan Emmons and the Waiakea Water brand which is now responsible for bringing clean water to areas of the world where drinking water is often seen as a luxury. Waiakea Water has now partnered with the Pump Aid group to bring more success to the charity already responsible for bringing clean water to more than one million people in rural Africa.

A sustainable approach to the provision of clean drinking water is always high on the list of priorities of Waiakea Water through the decision to remove only around one percent of the water sourced from the Mauna Loa volcano area to ensure no lasting damage is inflicted on the island.

Success in Dental Sleep Medicine with Dr Avi Weisfogel

Dr. Avi Weisfogel attended Rutgers University and graduated with a bachelor degree in Biology and Psychology. He later joined New York University and pursued a doctorate in Dental surgery. He began his career by establishing his dental care, the old bridge dental care in 1999.During that time he earned a name for himself from the community around as the best dentist. He also won the best dentist title for a couple of years. In 2010 he established a company known as Healthy heart Sleep which works with physicians around the world and advised on management of sleep labs.

Dr. Avi Weisfogel is passionate about his work and in his desire to help patients, he established Owner Unlimited patient sleep in the year 2012. Through this establishment, he teaches dentist on how to increase and serve patients with sleep apnea.As he further tried further to help patients, he invested and launched Dental sleep master’s program in the year 2014. The program’s primary purpose was to come up with appliances designed to provide relief for people suffering from sleep disorders. The primary specialty of the program is to provide orally applied therapy, which involves wearing a type of sleepwear which doesn’t obstruct breathing while sleeping. Dr.Avi has created a niche that never existed before. By combining his dentistry, sleep medicine and his marketing knowledge.

Dr. Avi has not only been involved in medicine and helping sleep patients but is also engaged in charity organizations, and donates much of his profits to them. Dr. Avi is a family man, and when not involved in work, he spends his time with his family. Dr. Avi, an avid reader, loves sports. He enjoys basketball, tennis and is a big fan of New York Knicks.

Dr. Avi is dedicated to his work and is committed to seeing both the doctors excel and the patient recovering. Dr Avis’s research and success is rare and in an area, that is challenging, and in spite of that, he has excelled. Dr Avi has learned a lot from his role model Steve Jobs, who he refers to as an outgoing person who holds high moral standards.

Mikhail Blagosklonny Works To Overcome Cancer And Aging

The world awaits the cure to cancer and a way to lessen the affects of aging. Mikhail Blagosklonny has been in the trenches working to help bring about these outcomes. His research helps to develop fresh anti-cancer methods and strategies as well as various cancer prevention and therapy methods. After receiving his MD in internal medicine and PhD in cardiology and experimental medicine from the First Pavlov State Medical University in St. Petersburg, Russia, he became an associate professor of medicine at the New York Medical College, Valhalla in 2002. After becoming a senior scientist at the Ordway Research Institute in Albany, New York, he was appointed Professor of Oncology at Roswell Park Cancer Institute in 2009. Dr. Blagosklonny believes that protecting normal body cells from chemo and radiotherapy, tissue specific and anti-tissue therapy, anti-cancer drugs selective combination and the slowdown of cancer by slowing down the aging process of the organisms. His research and discoveries fosters much hope for those who are fighting cancer and aging as well. Dr Blagosklonny also wants treatments to be available to all, not just the wealthiest clients and Mikhail’s lacrosse camp.

Dr. Mikhail Blagosklonny believes that it is possible to have a community free from cancer and aging effects. His research focuses on molecular biology, cellular biology, cell cycle, anti-cancer therapies, ontogenesis, clinical investigation and tumor suppressors. As a Professor of Oncology at Roswell Park Cancer Institute, he prepares his students to be active in creating a cancer free society and one free from the effects of aging. Dr. Blagosklonny also shares his research, hypothesis and developments through many publications to help the scientific community advance in knowledge and practices and learn more about Mikhail. He serves as an associate editor for many publications such as the International Journal for Cancer, the American Journal of Pathology and PLUS ONE. Mikhail Blagosklonny has published over 300 articles on various topics including chemotherapeutic engineering, cell cyclotherapy and aging hyperfunction theory. His cancer research has led to hypothesis that rapamycin can be used in humans to treat aging and prevent disease and more information click here.

Dr. Blagosklonny frowns on the description of aging as a disease and disagrees with the definition of aging as a functional decline caused by the accumulation of random molecular damage that cannot be prevented. Hyperfunction theory describes aging as a continuation of growth driven by signaling pathways. TOR (Target of Rapamycin) can be used to extend a healthy life span in humans. There are several potential anti-aging drugs in clinical use and combining drugs and modalities, selecting doses and schedules will avail the maximal lifespan extension. Mikhail Blagosklonny’s life work may be key to obtaining a better quality of life in the future by eliminating cancer and the effects of aging. Dr. Blagosklonny says that it may take 50 years for acceptance by the scientific community, yet the world can see it on the horizon, thanks to his research. Soon, perhaps, there will be a cancer free and ageless society, one experiencing a better quality of life and what Mikhail knows.

More Visit: https://scholar.google.com/citations?user=REO9YogAAAAJ&hl=en

Where Adam Goldenberg And Don Ressler Started, And Where They Are Today

Sometimes entrepreneurs find that their ultimate dream come true is actually much different than where they thought they might originally end up. That could summarize the stories of Adam Goldenberg and Don Ressler, two owners of a big fashion company known as Techstyle Fashion Group which started out as JustFab. Goldenberg and Ressler actually were on the team of developers and marketing agents that began the social media phenomenon known as MySpace before they arrived there, and it was in their years there that their careers were shaped.

 

Adam Goldenberg was a teenage marketing guru who had started tapping into internet advertising when he was only 15 and started his company Gamer’s Alliance. Don Ressler had started out as a consultant for companies looking to become e-commerce giants and take advantage of web space, and later on he started an online fitness product company known as FitnessHeaven.com. The two men came to the MySpace parent company Intermix Media’s headquarters after the company had bought out the small businesses they had founded, and Goldenberg even became Chief Operating Officer of Intermix Media, the youngest ever on a publicly-traded company at that time. Goldenberg and Ressler became friends because they found they shared a lot of the same vision and goals for Intermix Media and believed the sky was the limit to what they could do.

 

Goldenberg and Ressler helped found several subsidiary companies at Intermix Media and were looking to make MySpace into a big hub not only for social interaction, but also for turning into another eBay and retail space site. Their plans unfortunately didn’t get to go that way when News Corporation bought out the company and put Goldenberg and Ressler’s marketing strategies aside. So they decided to leave MySpace and start their own ecommerce branding company. It was that company, Intelligent Beauty that eventually gave way to their new idea, JustFab which became Techstyle Fashion Group.

 

Goldenberg and Ressler were not fashion experts when they got the idea to start the company, but they saw a niche that they felt they could put some ideas into. Living out in Los Angeles, they had their connections to several fashion stars and celebrities including Kimora Lee Simmons and later Kate Hudson. Those two women liked what Goldenberg and Ressler did because of their VIP subscription model and a new way of promoting their brands in ways that made products cheaper than most other fashion lines. But they also had the backing of investors such as Matrix Partners and several other venture capital companies that allowed JustFab to take root. Soon, they became a billion-dollar company and started opening up stores all across the nation. The name change to TechStyle was a reflection of a goal to include big data in with their sales tactics. https://onmogul.com/adam-goldenberg

Don Ressler Helping Fabletics Climb Ladder Of Success Uninterrupted

The fashion market has been evolving at a rapid pace in the last couple of decades, and many companies have been surfacing showcasing their strength as the trend changer. However, there has always been mild to the wild gap between functionality, fashion, and affordability. It is the case in the women sportswear segment as well, where women had to choose between style and functionality while almost always compromising with the affordability. It is this trend that was noticed by two brilliant entrepreneurs, Don Ressler and Adam Goldenberg. They realized that the segment of women’s athletic wear is not going to slow down anytime soon and thus, they co-founded Fabletics, which is an athleisure brand offering a broad range of athleisure designer wear for women from size XXS to 3XL.

 

The best part about Fabletics was that it didn’t catch the same bandwagon of fashion trends in the women’s athletic wear, but focused more on what women were looking for. It is what helped Fabletics make its niche in the fashion market. They found that many of the brands that offered good products cost a fortune and low-cost brands offered ill-fitted or garish products. There was hardly any brand that offered athleisure apparel at low cost while being good with design and fittings at the same time. And, it is this gap that Fabletics managed to fill successfully. To achieve their aim of providing consumers with high-quality products, both regarding design, fitting, and fabric quality, Kate Hudson was roped in as one of the partners. It also helped in making Fabletics a household brand among the women looking to lead a healthy lifestyle.

 

With Kate Hudson on board, Fabletics took off on a positive note and more and more women consumers not only started to recognize Fabletics as a brand but also became its loyal customers. The revenue of the company continued to multiply rapidly and in just a few years, managed to gain one million paid subscribers. Don Ressler had previous experience in the fashion industry, and he put in his experience at work to ensure that the fabric used in manufacturing the Fabletics athleisure wear were comfortable as well as high-quality. Fabletics also used the data-centric technology to its use and engaged in effective online marketing to reach out to potential customers worldwide, which helped the company jump the initial hurdles of commercialization in an otherwise highly competitive fashion market dominated by e-commerce brands like Amazon.

 

How Adam Goldenberg and Don Ressler have established Multi-Million Dollar Businesses

Techstyle Fashion Group is a reputable company that has various subsidiaries that have specialized in retailing quality clothing and accessories. The founders of the firm are Don Ressler and Adam Goldenberg, and they have been running it for the past seven years. The duo has built a multi-million dollar e-commerce enterprise by being able to solve the fashion needs of women across the United States. At 15 years old, Goldenberg had already joined the business world by founding Gamers Alliance. The company’s primary aim was to provide gaming websites with an excellent advertising network. Gamer Alliance was a profitable enterprise, and it was later sold to Intermix Media. In 1999, Adam was appointed to act as Intermix’s VP for strategic planning and had to quit school to take the position. At 20 years old, he was named as the COO of the company.

Don Ressler had gained a lot of experience as an entrepreneur before he started working at Intermix Media. He ran FitnessHeaven.com, which was a fitness-based website that was bought by Intermix in 2001. Ressler has also assisted various e-commerce enterprises in raising capital from investors to establish themselves. His experience in online businesses encouraged him to start investing in the fashion and beauty industries. Goldenberg and Ressler began their friendship when they were working at Alena Media, which was under Intermix Media.

The duo left Intermix Media in 2005 after it was sold to the News Corporation. In 2006, they teamed up with various experts who formerly served Alena Media and founded Intelligent Beauty. The firm acted as an incubator for different brands in the beauty and health sectors. Don and Adam then came up with the strategy of using membership plans in selling fashionable and comfortable athletic clothes through an e-commerce platform.

Techstyle has been in the fashion industry since 2010. The company was named JustFab during inception, and it offers the latest athleisure wear products to its customers every month. It received funding from different venture capitalists that include Matrix Partners. The fashion company was rebranded to Techstyle in 2016, and it currently comprises of different brands. Don and Adam act as its co-CEOs. They have used remarkable strategies in ensuring that the company’s customers are fully satisfied. The products that Techstyles sells to its clients are designed to make them feel sexy and comfortable. Its founders are devoted to growing it into the world’s leading online fashion company. http://www.entrepreneur.wiki/Adam_Goldenberg

Todd Lubar Helps Others Live Their Dream of Owning Property in Real Estate

President of TDL Global Ventures and Sr. Vice President of Legendary Investments, Todd Lubar is an entrepreneur with hopes of helping to teach others how they can fulfill their dreams. Todd has worked in the real estate background for more than 20 years. Todd has been ranked by Business.com at the top of the 25 Mortgage originators within the country during the last few years.

Todd Lubar has worked in other areas of the industry as well. He has maintained backgrounds within the entertainment industry as well as with construction and mortgage banking. He is very passionate with his desire to help the community learn the trade of successful business.

According to affiliatedork.com, in the 20 years of him working within the finance department and credit space, Todd knew he had to help others learn how they can live their dream of owning a home. He created a way to cut out the barriers which keep hopeful home owners away from the loans they need and created a product which allows for the consumer to get the relief they need.

Todd has worked hard his entire life to get to the point of success that he is at now. During high school, Todd worked locally at a grocery store for close to a year. He worked hard during the course of his year in grocery however he learned very quickly that this area of work is not what he longed for.

Todd Lubar first started out in the real estate bracket in 1995. When Todd first started out, he began his career at Crestar Mortgage Corp. This is where he initially entered into conservative banking. It was during this time period that Todd built long lasting relationships with real estate agents as well as CPA’s and financial planners along with the insurance agents.

1999 served as a good year for Todd as he then began another relationship with an equity position for Legacy Financial Group. This is what offered him the opportunity to be able to lend what he knows to others and help broker loans to the investors on the outside. Then in 2002, Todd decided he had to do more. This is when he formed Legendary Properties, LLC.

What You Need When Preparing for Life Line Screening’s Medical Tests

Life Line Screening has earned a good reputation for its cost-effective, painless, and non-invasive ultrasound screenings. The company also offers painless EKG for atrial fibrillation and blood screenings that require only a few drops of blood. As a patient seeking these services, you need to know that the screenings require little preparation.

Screening for Carotid Artery Disease and Atrial Fibrillation

For Carotid artery disease screening, a patient should wear a short-sleeved shirt that is open at the collar. Life Line Screening’s medical practitioners discourage people from wearing turtle neck shirts when seeking this medical service. Those seeking EKG for atrial fibrillation should wear loose two-piece clothing.

When visiting the doctor for atrial fibrillation screening, one should turn the cell phone off. One should not apply any lotion before visiting the doctor. Medics discourage such patients from wearing a pantyhose and a watch.

Abdominal Aortic Aneurysm

When being screened for this type of disorder, a patient should have loose two-piece clothing. One is also advised to avoid consuming any food four hours before the procedure begins. In cases where a person feels thirsty before being screened, she or he should take water moderately or sip 1/2 cup of tea or coffee. Diabetic patients are required to follow their care plans before seeking the service.

Ankle-brachial Index

This disease is commonly called the peripheral arterial disease. An individual who wants to be checked for this disease must wear loose two-piece clothing, comprising of short sleeved blouse or shirt. She or he must also avoid wearing pantyhose.

Glucose (type 2 diabetes) and hs-CRP (elevated C-reactive protein)

For both glucose and hs-CRP screenings, patients are required to fast for 8 hours. Medics usually test a person’s cholesterol level before checking for hs-CRP. They also carry tests on bone mineral intensity for those who want to know whether they have type 2 diabetes.

6 for Life Package and Elevated Liver Enzymes (ALT/AST)

One exciting thing about tests on the ALT/AST disease is that a person does not need to do any preparation. However, for 6 for Life Package, one is supposed to have fasted a minimum of eight hours before being tested for accurate results to be obtained. One should have short-sleeved blouse or shirt for blood pressure tests.

Life Line Screening Social Media: www.lifelinescreeningblog.com/

A Look At Some Of The Topics On Dr. Clay Siegall’s Blog

Seattle Genetics top executive, Clay Siegall, has a blog that covers a wide variety of topics. His most recent post is on Hurricane Irma and the threat it represents to those in the Carribean as well as potentially Florida or South Carolina depending on what path it takes. The article he posted, which appeared on NPR, tells people everything they need to know about the hurricane so that they can stay safe, hopefully by leaving the affected area before it strikes.

Clay Siegall is also a big NFL fan. He also posted an article he found on ESPN about the Baltimore Ravens quarterback, Joe Flacco. Due to injury, Joe Flacco missed the entire preseason. He will be ready for week one of the season, though. He said that the situation wasn’t ideal as he didn’t get in the work he needed in order to perform at his best. Nonetheless, he says he feels good and is prepared as he can be for the start of the season.

It was in 1998 that Clay Siegall co-founded Seattle Genetics. He works as the company’s chairman of the board, CEO, and president. His company creates targeted cancer therapies. The research they perform is on antibody drug conjugates which have shown great promise in successfully treating various types of cancer. The first drug he led to market was Adcetris which was approved by the FDA to treat two forms of lymphoma.

As the top executive at Seattle Genetics, Dr. Siegall is responsible for building strategic licensing alignments with other companies in the pharmaceutical industry. Some of the big names he has developed partnerships with are Roche, Pfizer, and AbbVie. So far these licensing agreements have resulted in $300 million in revenue being created for Seattle Genetics.

Clay Siegall is also responsible for raising capital for his company. He has brought in over $675 million through these fund raising efforts. He also led the company IPO which occurred in 2001.

Clay Siegall earned his Ph.D. in genetics at George Washington University. He earned his bachelor’s at the University of Maryland.